日本歯科大学新潟生命歯学部・先端研究センター


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はじめに

イメージ写真

食事や会話が楽しくできることは、人が心身共に健康で過ごすために重要なことです。
しかしながら、口腔内にガンができたり唾液が分泌しなくなって口が渇くと会話や食物の飲み込みが困難になります。また、噛み合わせが悪いと堅い食物が咬めないばかりか、時には頭痛や肩こりの原因となります。
本センターでは、このような口腔の機能に関わる疾患の原因を調べるため、また、その対策のために遺伝子工学的処方を用いて、あるいは新しい補綴物の開発、さらに組織再生のための基礎的な研究を行っています。


組織

再生医療学研究部門

構成員

構成員写真

土持 眞(センター長:歯科放射線学講座教授)

笹川一郎(教授:第1解剖併任)
佐藤 聡(教授:歯周病学講座併任)
宮川行男(教授:理工学併任)
青柳秀一(准教授)
久和彰江(准教授)
仲村健二郎(准教授)
田中 彰(准教授:新潟病院口腔外科併任)
鈴木見奈子(助教:口腔外科学講座併任)
相馬弘子(助教)
千葉朋義(助教:歯周病学講座併任)
中原 賢(助教:ベルン大学、スイス留学中)
馬島敏郎(客員教授:東北大学大学院医学系研究科)
坪川紀夫(客員教授:新潟大学工学部機能材料工学科)
川瀬知之(客員教授:新潟大学歯学部歯科基礎移植・再生学)



先端研究センター 研究年報

2006年

亀田 晃:医療トラブルの中の矯正歯科におけるトラブル、矯正歯科トラブルの法則−原因と結果、その傾向と対策−,序章、9-16,クインテッセンス出版,東京,2006.

亀田 剛:矯正治療におけるトラブル回避のための戦略的思考とは何か?−トラブルの本質からみた傾向と対策のための創造的戦略と戦術−矯正歯科トラブルの法則−原因と結果、その傾向と対策−第4章,67-95,クインテッセンス出版,東京,2006.

亀田 剛:公開された調査結果からみたわが国の矯正歯科料金の詳細,矯正歯科トラブルの法則−原因と結果,その傾向と対策−第5章,97-106,クインテッセンス出版,東京,2006.

Vidotto V, Ito-Kuwa S, Nakamura K, Aoki S, Melhem M, Fukushima K and others ( 7 in total). Extracellular enzymatic activities in Cryptococcus neoformans strains isolated from AIDS patients in different countries. Rev Iberoam Micol 2006; 23: 216-220.

Kiyohara N, Osafune T, Ehara T, Hachisuka H, Ito-Kuwa S, Aoki S. Immuno-electron microscopic studies on plastid DNA and photosynthetic proteins in Prototheca wickerhamii. Cytologia 2006; 71:309-314.

Koga H, Tsuji Y, Kanai K, Inoue K, Kasai T, Majima T and others (8 in total). In vitro antifungal activity of luliconazole against clinical isolates from dermatomycosis patients. J Infect Chemother 2006; 12: 163-165.

Iwasaki S, Yoshizawa H, Aoyagi H. Immunohistochemical expression of keratin 13 and 14 in the lingual epithelium of rats during the morphogenesis of filiform papillae. Arch Oral Biol 2006; 51: 416-426.

Iwasaki S, Aoyagi H, Asami T. Expression of keratin 18 in the periderm cells of the lingual epithelium of fetal rats: visualization by fluorescence immunohistochemistry and differential interference contrast microscopy. Odontology 2006; 94(1): 64-68.

Sasagawa I, Ishiyama M, Akai J. Cellular influence in the formation of enameloid during odontogenesis in bony fishes, Mat Sci Eng C 2006; 26: 630-634.

亀田 剛, 石渡佐知子, 春藤 勲, 秋山真人, 吉田 満, 小菅直樹, 亀田晃:矯正治Bite closing の口蓋容積に対する影響−,甲北信越矯正歯誌 2006; 14:1-6.

Kameda T,Akiyama M,Shundou I,Ishiwatari S,Yoshida M,Kosuge N and other (7 in total). Palatal Volume changes in orthodontic treatment−Part1.Angle class I crowding cases of patients with growth period−. J Begg Orthod 2006; 28:1-7.

Kameda T,Shundou I,Ishiwatari S,Akiyama M,Kosuge N,Yoshida M and other (7 in total). Palatal Volume changes in orthodontic treatment−Part2.Deep bite cases treated by bite opening for patients with growth period−. J Begg Orthod 2006; 28:8-14.

Kameda T,Shundou I,Ishiwatari S,Yoshida M,Kosuge N,Kameda A. Variation of cross sectional shapes and sizes of orthodontic squire/rectangular wires for multibracket system−Part1.Nickel titanium shape memory wires−. J Begg Orthod 2006; 28:15-20.

Kameda T,Ishiwatari S,Shundou I, Kosuge N,Yoshida M, Kameda A. Variation of cross sectional shapes and sizes of orthodontic squire/rectangular wires for multibracket system−Part2.Stainless steel wires−. J Begg Orthod 2006; 28:21-26.

Yoshida M, Kameda T, Oguni T, Kosuge N, Kameda A. A study on etiologic factors of root resorption in orthodontic treatment of crowding cases. J Begg Orthod 2006; 28:27-35.

2007年

Osafune T, Mitsuboshi M, Ito T, Aoki S, Ehara T, Hashiguchi M and others (7 in total). Analysis of bacterial flora in dohyo soil. Env Health Prev Med 2007; 12: 11-16.

Ito-Kuwa S, Nakamura K, Aoki S, Vidotto V. Serotype identification of Cryptococcus neoformans by multiplex PCR. Mycoses 2007; 50: 277-281.

南部弘喜,又賀 泉,青木茂治: 口腔カンジダ症患者由来 Candida albicans 株の分子生物型と生化学的性状, 口科誌, 2007; 56: 374-384.

Soma H, Miyagawa Y. Development of metal-resin composite for dental magnet keepers. Part 1: Effects of filler and 4-META contents on setting and flexural properties. Dent Mater J 2007; 26: 129-134.

Iwasaki S, Aoyagi H, Yoshizawa H. Immunohistochemical detection of epidermal growth factor and epidermal growth factor receptor in the lingual mucosa of rats during the morphogenesis of filiform papillae. Acta Histochemica 2007; 109: 37-44.

Iwasaki S, Aoyagi H. Expression of keratin 14 in the basal cells of the lingual epithelium of mice during the morphogenesis of filiform papillae: visualization by fluorescent immunostaining and confocal laser scanning microscopy in the transmission mode. Odontology 2007; 95: 61-65.

Kameda T, Yoshida M, Kosuge N, Kameda A. Material characteristic study of orthodontic beta-titan wires for multibracket systems. J Begg Orthod 2007; 29: 15-19.

Kameda T, Yoshida M, Kosuge N, Kameda A. Variation of impacted teeth in orthodontic treatment. J Begg Orthod 2007; 29: 20-25.

Kameda T, Yoshida M, Kosuge N, Kameda A. Deep overbite cases treated only with the KB multibracket system. J Begg Orthod 2007; 29: 26-36.

Matsumura C, Kuwashima H, Soma S, Kimura T. Effects of genistein and herbimycin, tyrosine kinase inhibitors, on catecholamine release in bovine adrenal chromaffin cells. Auton Autacoid Pharmacol 2007; 27: 181-187.

2008年

Amanai T, Nakamura Y, Aoki S, Magata I. Micro-CT analysis of experimental Candida osteoarthrits in rats. Mycopathologia 2008; 166: 133-141.

Ito-Kuwa S, Nakamura K, Valderrama B, Aoki S, Vidotto V, Osafune T. Diversity of laccase among Cryptococcus neoformans serotypes. Microbiol Immunol 2008; 52: 492-498.

Goto S, Churnjitapirom P, Miyagawa Y, Ogura H. Effect of additive metals, Sn, Ga, and In in Ag-Pd-Au-Cu alloys on initial bond strength of 4-META adhesive cement to these alloys. Dent Mater J 2008; 27: 678-686.

Sasagawa I, Ishiyama M, Yokosuka H, Mikami M. Fine structure and development of the collar enamel in gars, Lepisosteus oculatus, Actinopterygii. Frontiers of Materials Science in China 2008; 2: 134-142.

Aoyagi H, Asami T, Yoshizawa H, Wanichanon C, Iwasaki S. Newly developed technique for dual localization of keratin 13 and 14 by fluorescence immunohistochemistry. Acta Histochemica 2008; 110: 324-332.

Asami T, Aoyagi H, Yoshizawa H, Wanichanon C, Iwasaki S. Immunohistochemical expression of type II collagen in the lingual mucosa of rats during organogenesis of the tongue. Archives of Oral Biology 2008; 53: 622-628.

Iwasaki S, Asami T, Wanichanon C, Yoshizawa H, Aoyagi H. Immunohistochemical analysis of type III collagen expression in the lingual mucosa of rats during organogenesis of the tongue. Odontology 2008; 95: 61-65.

Aoyagi H, Iwasaki S. Long-term effect of silver powder in vivo. Dental Materials Journal 2008; 27: 612-625.

亀田 剛, 小菅直樹, 亀田 晃, マルチブラケット用ニッケルチタンワイヤーのサイズと断面形状の多様性, 日本成人矯正歯科学会雑誌 2008, 15巻1号, 7-13.

Kameda T, Kosuge N, Kameda A. Variation of sizes and cross sectional forms in Ni-Ti rectangular wires for multibracket systems. J Jpn Assoc Adult Orthod 2008; 15: 7-13.

亀田 剛, 小菅直樹, 亀田 晃, マルチブラケット用ステンレススチールワイヤーのサイズと断面形状の多様性, 日本成人矯正歯科学会雑誌 2008, 15巻1号, 14-20.

Kameda T, Kosuge N, Kameda A. Variation of sizes and cross sectional forms in stainless steel rectangular wires for multibracket systems. J Jpn Assoc Adult Orthod 2008; 15: 4-20.

Kameda T, Kosuge N, Kameda A. Influences of dimensional, cross sectional areas and shapes of Ni-Ti rectangular wires on bracket-wire friction, Journal of Begg Orthodontics 2008, vol.30 no.1, 6-11.

Kameda T, Kosuge N, Kameda A. Influences of dimensional, cross sectional areas and shapes of stainless steel rectangular wires on bracket-wire friction, Journal of Begg Orthodontics 2008, vol.30 no.1, 12-17.

2009年

Lamping E, Ranchod A, Nakamura K, Tyndall JDA, Niimi K, Holmes AR, Niimi M, Cannon RD. Abc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei. Antimicrob Agents Chemother 2009; 2: 354-369.

Sasagawa I, Ishiyama M, Yokosuka H, Mikami M and Uchida T. Tooth enamel and enameloid in actinopterygian fish. Frontiers of Materials Science in China 2009; 3: 174-182.

近藤貴彦,畑 好昭,青柳秀一,渡邊文彦:クトロフォーミング法と陶材によるキャスタブルセラミック(OCC)の補強効果,日本補綴歯科学会誌 2009: 1巻4号: 403-411.

Kondo T, Hata Y, Aoyagi H, Watanabe F. Reinforcing effect of castable ceramics (OCC) by electroforming technique and porcelain. Ann Jpn Prosthodont Soc 2009; 1: 403-411.

Kameda T, Kameda A. Mechanism of crowding correction between Hellman’s developing stage IIIB and IVA. Journal of Begg Orthodontics 2009; 31: 11-14.

Kameda T, Kameda A. Mechanism of crowding correction between Hellman’s developing stage IVA and VA. Journal of Begg Orthodontics 2009; 31: 15-18.

Soma S, Kuwashima H, Matsumura C, Kimura T. Involvement of protein kinase C in the regulation of Na+/Ca2+ exchanger in bovine adrenal chromaffin cells. Clin Exp Pharmacol Physiol 2009; 36: 717-723.

2010年

Iwasaki S, Aoyagi H: Fluorescence immunohistochemistry in combination with differential interference contrast microscopy for studies of semi-ultrathin specimens of epoxy resin-embedded samples (Chapter 14), In: Methods in Molecular Biology Vol. 689, Light Microscopy Methods and Protocols (Eds. H. Charini-Garcia & R. C. N. Melo) pp. 229-240, 2010, Humana Press c/o Springer Science + Business Media, New York, USA.

亀田 晃,亀田 剛:最新のKBテクニック:改良型ベッグ法の実際―インナービューティを考慮した矯正歯科治療へ―,クインテッセンス出版,東京,2010.

菅原芳秋,久和彰江,中栄正隆,柴崎浩一:CHROagar Candida dubliniensis 検出法の検討,新臨技会誌 2010; 50: 65-68.

Aoyagi H, Tsuchikawa K, Iwasaki S. Three-dimensional observation of the mouse embryo by micro-computed tomography: composition of the trigeminal ganglion.  Odontology 2010; 98: 26-30.

Kameda T, Kameda A. Development of a new elastomeric module with low coloration by foods and drinks -Part 1. Coloration by various kinds of foods and drinks,  Journal of Begg Orthodontics 2010; 32: 13-17.

Kameda T, Kosuge N, Kameda A. Development of a new elastomeric module with low coloration by foods and drinks -Part 2. Friction between brackets and wires, and mechanical strength,  Journal of Begg Orthodontics 2010; 32: 18-20.

外部研究費

2006年

1)委託研究費,小倉英夫(代表),後藤真一,宮川行男(分担),低熱膨張の超低融陶材焼付用合金の開発研究.

2)日本学術振興会科学研究費補助金、基盤研究(C)一般 (継続)、笹川一郎(代表者)、エナメル質とエナメロイドの比較による結晶形成機構の研究
成果

2007年

1)委託研究費,小倉英夫(代表),後藤真一,宮川行男(分担),低熱膨張の超低融陶材焼付用合金の開発研究

2008年

1)委託研究費,小倉英夫(代表),後藤真一,宮川行男(分担),低熱膨張の超低融陶材焼付用合金の開発研究

2009年

1)委託研究費,小倉英夫(代表),宮川行男,後藤真一,赫多 清,大熊一夫(分担),低熱膨張の超低融陶材焼付用合金の開発研究.